Creamy Cajun Chicken Pasta Lite

Featured in: Everyday Home Meals

Creamy Cajun Chicken Pasta Lite transforms a comfort classic into a lighter option without sacrificing flavor. Juicy chicken strips are seasoned with Cajun spices and paprika, then combined with sautéed bell peppers and red onion in a smooth, creamy sauce made with reduced-fat cream cheese and low-fat milk. Al dente whole wheat penne ties everything together with bright notes of lemon and fresh parsley. This 40-minute main course delivers 420 calories per serving with 32g protein, making it perfect for weeknight dinners that satisfy both your palate and health goals.

Updated on Tue, 20 Jan 2026 12:21:00 GMT
Creamy Cajun Chicken Pasta Lite features juicy chicken strips and penne in a spicy, reduced-fat sauce, garnished with fresh parsley and lemon zest.  Pin It
Creamy Cajun Chicken Pasta Lite features juicy chicken strips and penne in a spicy, reduced-fat sauce, garnished with fresh parsley and lemon zest. | ovenanchor.com

The kitchen filled with that unmistakable Cajun spice aroma when I first experimented with lightening up this classic. I'd been craving something creamy and spicy but didn't want the heaviness that usually comes with it. My husband looked skeptical when I mentioned reduced-fat cream cheese, but one bite changed his mind completely. Now it's become our go-to when we want restaurant-quality comfort food without the post-dinner regret.

Last winter, my sister came over exhausted from work and I made this for her. She took one bite, closed her eyes, and said this was exactly what she didn't know she needed. We sat at the counter eating straight from the pan, talking and laughing, and she asked for the recipe before she even finished her serving. Something about that perfect balance of heat and creaminess just makes people slow down and savor it.

Ingredients

  • Whole wheat penne: The nutty flavor stands up beautifully to bold Cajun spices and adds fiber that keeps you full
  • Chicken breasts: Slice them into even strips so they cook uniformly and stay juicy
  • Cajun seasoning: This is your flavor powerhouse, so don't be shy with it
  • Smoked paprika: Adds that gorgeous deep color and subtle smoky undertone
  • Bell peppers: Red and yellow bring natural sweetness that balances the heat perfectly
  • Reduced-fat cream cheese: Creates that luscious sauce base without the heavy cream guilt
  • Low-fat milk: Thins the sauce just enough while keeping it silky smooth
  • Lemon: Both zest and juice cut through the richness and brighten every bite
  • Fresh parsley: Don't skip it, that pop of green and fresh flavor makes the dish sing

Instructions

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Get your pasta going:
Drop that penne into boiling salted water and cook it until it's got that perfect al dente bite, then drain but save some of that starchy water like liquid gold
Season your chicken:
Toss those strips in a bowl with all your spices until they're evenly coated and smelling incredible
Sear the chicken:
Heat your olive oil in a big skillet and cook the chicken until it's golden on the outside and cooked through, then set it aside on a plate
Cook the vegetables:
In that same flavorful pan, sauté your peppers and onion until they're softened and fragrant, then add the garlic for just one minute so it doesn't burn
Build that creamy sauce:
Lower the heat, return the chicken to the pan, and stir in your cream cheese and milk until everything melts together into silky perfection
Bring it all together:
Stir in the Parmesan, lemon zest and juice, then toss in your cooked pasta and mix until every piece is coated in that gorgeous sauce
Finish and serve:
Taste and adjust the seasoning if needed, then sprinkle with fresh parsley and watch everyone's eyes light up
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A light skillet of Cajun chicken pasta with bell peppers, creamy sauce, and al dente whole wheat penne, ready for a weeknight dinner.  Pin It
A light skillet of Cajun chicken pasta with bell peppers, creamy sauce, and al dente whole wheat penne, ready for a weeknight dinner. | ovenanchor.com

This recipe became a total game-changer during my health journey last year. I could still have the rich, comforting pasta dishes I loved while staying on track with my goals. Now it's the meal I make when I want to show someone that eating light doesn't mean sacrificing flavor or satisfaction.

Making It Your Own

I've discovered that swapping chicken for shrimp works beautifully here, and cooking time drops to just 2-3 minutes per side. Sometimes I throw in some baby spinach at the very end for extra nutrition, letting it wilt slightly in that hot sauce. My friend uses cauliflower florets instead of pasta for a keto version and swears it's just as satisfying.

Perfecting The Sauce

The key is getting your cream cheese to room temperature before adding it to the pan, otherwise you might end up with little lumps that refuse to melt smoothly. I've learned to grate my own Parmesan fresh because the pre-grated stuff has anti-caking agents that can make the sauce grainy. And that lemon juice should be added at the very end to preserve its bright, fresh pop.

Serving Suggestions

A simple green salad with a vinaigrette cuts through the richness beautifully, and I love serving it with some crusty whole grain bread to soak up any extra sauce. Sometimes I'll roast some broccoli or asparagus on the side for a complete meal that feels indulgent but is actually quite balanced.

  • Let the sauce rest for a minute off the heat before serving to let it thicken slightly
  • Always zest your lemon before juicing it, it's so much easier that way
  • If you're meal prepping, store the pasta and sauce separately and reheat gently with a splash of water
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Garnished with parsley and lemon, this lower-calorie Cajun chicken pasta offers a creamy, spicy bite with colorful peppers and onions. Pin It
Garnished with parsley and lemon, this lower-calorie Cajun chicken pasta offers a creamy, spicy bite with colorful peppers and onions. | ovenanchor.com

I hope this becomes one of those recipes you turn to again and again, whether you're feeding a crowd on a weeknight or just treating yourself to something special on a quiet Sunday evening.

Recipe FAQs

Can I use regular pasta instead of whole wheat?

Yes, absolutely. Regular penne works perfectly and will cook in about the same time. Adjust cooking time slightly if using a different pasta shape, aiming for al dente texture.

How can I make this spicier?

Add a pinch of cayenne pepper to the Cajun seasoning blend, or increase the Cajun seasoning amount by an extra half teaspoon. You can also add red pepper flakes directly to the sauce for more heat.

What are good substitutes for chicken?

Shrimp works wonderfully and cooks in just 2-3 minutes. Tofu is an excellent vegetarian option—press it first and season the same way. Turkey breast strips are another lean alternative.

How long do leftovers last?

Store covered in the refrigerator for up to 2 days. Reheat gently on the stovetop over medium heat, adding a splash of milk if the sauce thickens. This dish is best enjoyed fresh but reheats well.

Can I make this dairy-free?

Substitute reduced-fat cream cheese with dairy-free cream cheese, low-fat milk with unsweetened almond or oat milk, and Parmesan with nutritional yeast. The sauce will be slightly lighter but still creamy and flavorful.

Why reserve pasta water?

Pasta water contains starch that helps loosen and emulsify the sauce, making it silkier and helping it coat the noodles better. Use it only if needed to reach your desired sauce consistency.

Creamy Cajun Chicken Pasta Lite

Tender chicken and penne tossed in a spicy, creamy Cajun sauce with reduced fat. Guilt-free indulgence ready in 40 minutes.

Prep Duration
15 minutes
Cook Duration
25 minutes
Overall Time
40 minutes
Recipe by Luke Murphy


Level of Challenge Easy

Cuisine American (Cajun-inspired)

Serves 4 Portions

Diet Compatibility None specified

Ingredient List

Pasta

01 10 oz whole wheat penne

Chicken

01 2 large boneless, skinless chicken breasts (14 oz), sliced into strips
02 1 tablespoon olive oil
03 1 teaspoon Cajun seasoning
04 1/2 teaspoon smoked paprika
05 1/2 teaspoon garlic powder
06 1/2 teaspoon salt
07 1/4 teaspoon black pepper

Vegetables

01 1 red bell pepper, thinly sliced
02 1 yellow bell pepper, thinly sliced
03 1 small red onion, thinly sliced
04 2 cloves garlic, minced

Sauce

01 2/3 cup reduced-fat cream cheese
02 1/2 cup low-fat milk
03 1/4 cup grated Parmesan cheese
04 Zest and juice of 1/2 lemon
05 1 tablespoon fresh parsley, chopped

Steps

Step 01

Cook Pasta: Cook penne according to package instructions until al dente. Drain and set aside, reserving 1/4 cup pasta water.

Step 02

Season Chicken: In a medium bowl, toss chicken strips with Cajun seasoning, smoked paprika, garlic powder, salt, and black pepper.

Step 03

Sear Chicken: Heat olive oil in a large skillet over medium-high heat. Add seasoned chicken and sauté for 4 to 5 minutes until golden and cooked through. Remove chicken and set aside.

Step 04

Cook Vegetables: In the same skillet, add sliced bell peppers and red onion. Sauté for 4 to 5 minutes until softened. Add minced garlic and cook for 1 minute more.

Step 05

Create Sauce: Lower heat to medium. Return chicken to the skillet. Add cream cheese and milk, stirring constantly until smooth and creamy. Add reserved pasta water as needed to achieve desired consistency.

Step 06

Finish Dish: Stir in Parmesan cheese, lemon zest, and juice. Add cooked penne and toss to combine. Season to taste.

Step 07

Serve: Garnish with chopped fresh parsley and serve immediately.

Tools Needed

  • Large pot
  • Large skillet
  • Wooden spoon or spatula
  • Knife and cutting board
  • Measuring cups and spoons

Allergy Details

To spot allergens, check each component. When uncertain, talk with your healthcare provider.
  • Contains milk (cream cheese, Parmesan, milk)
  • Contains wheat (pasta)
  • Verify Cajun seasoning for potential allergens and gluten content

Nutrition Details (per serving)

Nutritional details are meant for general info. Please consult a doctor for personalized advice.
  • Caloric Value: 420
  • Fats: 10 grams
  • Carbohydrates: 52 grams
  • Proteins: 32 grams