Grilled Chicken Spinach Panini

Featured in: Oven-Cooked Main Dishes

A delicious Italian-American main dish that comes together in just 30 minutes. Tender grilled chicken breasts are seasoned with Italian herbs, sliced thin, and layered with fresh spinach, mozzarella, and Parmesan on bread spread with aromatic garlic butter. The panini is pressed until the cheese melts and the bread turns golden and crispy. Perfect for lunch or dinner, this savory sandwich serves four and pairs wonderfully with a green salad or tomato soup.

Updated on Sun, 18 Jan 2026 12:48:00 GMT
Golden-brown Grilled Chicken Spinach Panini on rustic bread, revealing melted mozzarella and fresh spinach when sliced open. Pin It
Golden-brown Grilled Chicken Spinach Panini on rustic bread, revealing melted mozzarella and fresh spinach when sliced open. | ovenanchor.com

The smell of garlic butter hitting hot bread is what sold me on paninis forever. I used to think they were just fancy grilled cheese until a friend made me one with actual grilled chicken and spinach tucked inside. The crunch of the golden crust against the soft, melty center changed my mind in one bite. Now I keep cooked chicken in my fridge just so I can throw these together on busy nights. They taste like effort but come together faster than ordering takeout.

I started making these on weeknights when my kids were tired of the same rotation of dinners. They loved anything they could pick up with their hands, and I loved sneaking spinach past them without a fight. The first time I served these, my youngest asked if we were having restaurant food. I didnt correct her. It became our Thursday tradition for a while, and I still get requests for it when someone needs cheering up.

Ingredients

  • Boneless, skinless chicken breasts: These grill up fast and slice cleanly, but you can absolutely use rotisserie chicken or leftover grilled thighs to save time.
  • Olive oil: Brushing the chicken keeps it moist on the grill and adds a subtle richness that plays well with the garlic butter.
  • Salt, black pepper, and dried Italian herbs: Simple seasoning that lets the chicken shine without competing with the garlic and cheese.
  • Unsalted butter: Softened butter spreads easily and crisps the bread perfectly when pressed, and using unsalted lets you control the salt level.
  • Garlic cloves: Fresh garlic makes all the difference here, it gets sweet and mellow as the butter melts into the bread.
  • Fresh parsley: A little brightness that cuts through the richness and makes the garlic butter taste more intentional.
  • Rustic Italian or sourdough bread: Sturdy enough to hold up to pressing and thick enough to get crispy outside while staying soft inside.
  • Fresh baby spinach: Wilts just enough under the heat and adds color and nutrition without any bitterness.
  • Shredded mozzarella cheese: Melts beautifully and gives you those stretchy, gooey pulls everyone loves in a panini.
  • Grated Parmesan cheese: Adds a salty, nutty depth that makes the whole sandwich taste more grown up.

Instructions

Product image
Provides cushioned support while cooking, washing dishes, and standing longer during meal preparation.
Check price on Amazon
Grill the chicken:
Preheat your grill pan or outdoor grill to medium high heat. Brush the chicken breasts with olive oil and season both sides with salt, pepper, and Italian herbs, then grill for 5 to 6 minutes per side until the internal temperature hits 165 degrees and the juices run clear.
Rest and slice:
Let the chicken rest for 5 minutes so the juices redistribute, then slice it thinly against the grain. Thin slices make the sandwich easier to bite through and help the flavors blend better.
Make the garlic butter:
In a small bowl, mix the softened butter with minced garlic and chopped parsley until combined. The parsley should be finely chopped so it melts into the butter rather than sitting in clumps.
Assemble the sandwiches:
Lay out all 8 slices of bread and spread garlic butter on one side of each slice. On the unbuttered side of 4 slices, layer the sliced chicken, a handful of spinach, mozzarella, and a sprinkle of Parmesan, then top with the remaining bread slices with the buttered side facing out.
Press and cook:
Heat your panini press or a large skillet over medium heat. Place the sandwiches in the press or skillet, using a heavy pan to weigh them down if youre using a skillet, and cook for 3 to 5 minutes per side until the bread is golden brown and the cheese is fully melted.
Serve hot:
Slice each panini in half on the diagonal and serve immediately while the cheese is still stretchy and the bread is crisp. They lose their magic once they cool down too much.
Product image
Provides cushioned support while cooking, washing dishes, and standing longer during meal preparation.
Check price on Amazon
Steam rising from a hot Grilled Chicken Spinach Panini, with juicy grilled chicken and melty cheese inside. Pin It
Steam rising from a hot Grilled Chicken Spinach Panini, with juicy grilled chicken and melty cheese inside. | ovenanchor.com

One evening I made these for a friend who had just moved and was living out of boxes. We sat on her floor with paper towels as plates, and she said it was the first real meal shed had in days. The panini was still warm, cheese stretching between bites, and it felt like such a small thing to make but it mattered. Food does that sometimes, it shows up right when someone needs it to feel like home again.

Choosing Your Bread

The bread is half the sandwich, so it matters more than you think. I like a rustic Italian loaf or sourdough because theyre sturdy enough to press without falling apart and they have enough chew to stand up to the fillings. Avoid soft sandwich bread, it turns into mush under pressure. If your bread is pre sliced, make sure the slices are at least half an inch thick. Day old bread actually works better than fresh because it crisps up without getting too dense.

Swapping the Protein

Chicken is what I use most, but turkey breast works just as well and tastes a little lighter. Rotisserie chicken is my shortcut when I dont feel like grilling, just shred it and pile it on. Ive even used leftover steak once, sliced thin, and it turned the panini into something almost fancy. If youre vegetarian, skip the meat entirely and add roasted red peppers or grilled zucchini for substance. The garlic butter and cheese carry enough flavor that the sandwich still feels complete.

Storing and Reheating

These are best eaten fresh, but if you have leftovers, wrap them tightly in foil and store them in the fridge for up to two days. Reheat them in a skillet over medium heat to bring back some of the crispness, the microwave will make them soggy. You can also freeze assembled but uncooked sandwiches wrapped in parchment and foil, then cook them straight from frozen, adding a few extra minutes to the press time. I sometimes make a double batch and freeze half for nights when I dont want to think.

  • Wrap leftovers tightly in foil and refrigerate for up to two days.
  • Reheat in a skillet, not the microwave, to restore the crispy texture.
  • Freeze uncooked assembled sandwiches and cook directly from frozen when needed.
Product image
Quickly cook hard boiled, poached, or scrambled eggs and omelets for easy breakfasts and meal prep.
Check price on Amazon
A cross-section of a Grilled Chicken Spinach Panini, showing tender chicken slices and vibrant spinach layered with Parmesan. Pin It
A cross-section of a Grilled Chicken Spinach Panini, showing tender chicken slices and vibrant spinach layered with Parmesan. | ovenanchor.com

This panini has become my answer to whats for dinner when I dont have an answer. It feels generous and tastes indulgent, but it never asks too much of me, and thats exactly the kind of recipe I come back to again and again.

Recipe FAQs

Can I prepare the chicken in advance?

Yes, grill the chicken up to 24 hours ahead and store it in an airtight container in the refrigerator. Slice it just before assembling your panini for best results.

What if I don't have a panini press?

A large skillet works perfectly as an alternative. Place the sandwich in the skillet over medium heat and weigh it down with a heavy pan or cast iron skillet on top for 3-5 minutes per side until golden.

How do I prevent the bread from burning while the cheese melts?

Cook over medium rather than high heat, and keep the cooking time to 3-5 minutes per side. You can also cover the skillet with a lid to trap heat and melt the cheese faster.

Can I make this vegetarian?

Absolutely. Replace the chicken with grilled portobello mushrooms, eggplant, or zucchini. Season them the same way with olive oil and Italian herbs, then grill until tender.

What cheeses work best for this panini?

Mozzarella and Parmesan are traditional choices that melt beautifully. Provolone adds a sharper flavor, while fontina or smoked gouda can provide interesting variations.

How should I store leftovers?

Store cooled panini in an airtight container in the refrigerator for up to 2 days. Reheat in a skillet or oven at 350°F for about 10 minutes to restore crispness.

Grilled Chicken Spinach Panini

Warm, savory panini featuring juicy grilled chicken, fresh spinach, melty cheese, and garlic butter on crusty bread.

Prep Duration
15 minutes
Cook Duration
15 minutes
Overall Time
30 minutes
Recipe by Luke Murphy


Level of Challenge Easy

Cuisine Italian-American

Serves 4 Portions

Diet Compatibility None specified

Ingredient List

Chicken

01 2 boneless, skinless chicken breasts
02 1 tablespoon olive oil
03 1/2 teaspoon salt
04 1/2 teaspoon black pepper
05 1/2 teaspoon dried Italian herbs

Garlic Butter

01 3 tablespoons unsalted butter, softened
02 2 cloves garlic, minced
03 1 tablespoon fresh parsley, finely chopped

Panini

01 8 slices rustic Italian or sourdough bread
02 2 cups fresh baby spinach, washed and dried
03 1 1/2 cups shredded mozzarella cheese
04 1/2 cup grated Parmesan cheese
05 Olive oil for brushing

Steps

Step 01

Heat grill surface: Preheat a grill pan or outdoor grill to medium-high heat.

Step 02

Grill chicken breasts: Brush chicken breasts with olive oil and season with salt, pepper, and dried Italian herbs. Grill for 5 to 6 minutes per side until cooked through. Allow to rest for 5 minutes, then slice thinly.

Step 03

Prepare garlic butter: In a small bowl, combine softened butter, minced garlic, and freshly chopped parsley until well blended.

Step 04

Assemble bread: Arrange bread slices on work surface. Spread garlic butter mixture on one side of each slice.

Step 05

Build panini: On the unbuttered side of 4 bread slices, layer grilled chicken slices, fresh spinach, mozzarella cheese, and Parmesan cheese in sequence. Top each with remaining bread slices, buttered side facing outward.

Step 06

Toast panini: Heat a panini press or large skillet over medium heat. Place assembled sandwiches in the press or skillet, using a heavy pan to weight down if necessary. Cook 3 to 5 minutes per side until bread achieves golden color and cheese is fully melted.

Step 07

Finish and serve: Slice each panini diagonally in half and serve immediately while hot.

Tools Needed

  • Grill pan or outdoor grill
  • Panini press or large skillet
  • Mixing bowl
  • Knife and cutting board

Allergy Details

To spot allergens, check each component. When uncertain, talk with your healthcare provider.
  • Contains wheat from bread
  • Contains milk from cheese and butter
  • May contain traces of gluten; verify bread labels for celiac concerns
  • May contain traces of dairy; verify cheese labels for lactose sensitivity

Nutrition Details (per serving)

Nutritional details are meant for general info. Please consult a doctor for personalized advice.
  • Caloric Value: 450
  • Fats: 20 grams
  • Carbohydrates: 35 grams
  • Proteins: 32 grams